DescriptionOverview The Center for Drug Discovery (CDD) is a multi-disciplinary center comprised of chemists and pharmacologists working together to discover new therapeutics in a non-profit setting. Our work is funded by federal agencies, such as the NIH and FDA, through grants and contracts in addition to various commercial entities. CDD is currently seeking to grow its federal and commercial computational chemistry offerings, which creates the need for a Computational Chemist to join our team of established researchers Ideally, you will previous experience in a pharmaceutical, biotech, or academic/non-profit setting. We are particularly interested in candidates with experience in the design and development of new drug candidates using in silico approaches. In this new and exciting role, you will support a team of researchers working on diverse molecular targets, largely but not exclusively focusing on G-protein-coupled receptors(GPCRs). To be successful in this role, you will be capable of managing collaborations and building strong relationships with peers and clients. This position is located at our headquarters in Research Triangle Park, NC, an area that is consistently ranked as one of the top places to live in the US with moderate cost of living and excellent public schools. Responsibilities Integrate into RTI’s drug discovery business through in silico federal/commercial research activities. Collaborate with medicinal chemists and pharmacologists as a technical expert. Assist with ongoing NIH-funded grants and solicit new funding as appropriate. Assist with management of in-house chemical databases. Qualifications PhD with 5 years of experience in chemistry, medicinal chemistry, physical chemistry, pharmaceutical science, or a related field. Demonstrated understanding of and experience in drug discovery research. A background in theory underlying computational investigations: molecular-mechanics/quantum-mechanics/thermochemistry is desired. Demonstrated experience writing and compiling computational-chemistry code, including C++/Java/Fortran coding experience. Demonstrated Linux/Unix platform and scripting/coding experience. Preferred: Experience in machine learning/AI with underpinnings to support medicinal chemistry drug-discovery. Previous experience in both structure-based and ligand-based drug design. Previous experience with in silico ADMET assessments, using computational methods. EEO & Pay Equity Statements For San Francisco, CA USA Job Postings Only: Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Further information is available here. RTI accepts applications to our job openings from candidates with criminal histories or conviction records in accordance with all applicable laws, including the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. The anticipated pay range for this role is listed below. Our pay ranges represent national averages and may vary by location as a geographic differential may be applied to some locations within the United States. RTI considers multiple factors when making an offer including, for example: established salary range, internal budget, business needs, and education and years of work experience possessed by the applicant. Further, salary is merely one element to our offer. At RTI, we demonstrate our commitment to rewarding individual and team achievement through a total rewards package. This package includes (among other things) a competitive base salary, a generous paid time off policy, merit based annual increases, bonus opportunities and a robust recognition program. Other benefits include a competitive range of insurance plans (including health, dental, life, and short-term and long-term disability), access to a retirement savings program such as a 401(k) plan, paid parental leave for all parents, financial assistance with adoption expenses or infertility treatments, financial reimbursement for education and developmental opportunities, an employee assistance program, and numerous other offerings to support a healthy work-life balance. Equal Pay Act Minimum/Range $116,000-$142,000
ResponsibilitiesIntegrate into RTI’s drug discovery business through in silico federal/commercial research activities. Collaborate with medicinal chemists and pharmacologists as a technical expert. Assist with ongoing NIH-funded grants and solicit new funding as appropriate. Assist with management of in-house chemical databases
QualificationPhD with 5 years of experience in chemistry, medicinal chemistry, physical chemistry, pharmaceutical science, or a related field. Demonstrated understanding of and experience in drug discovery research. A background in theory underlying computational investigations: molecular-mechanics/quantum-mechanics/thermochemistry is desired. Demonstrated experience writing and compiling computational-chemistry code, including C++/Java/Fortran coding experience. Demonstrated Linux/Unix platform and scripting/coding experience. Preferred: Experience in machine learning/AI with underpinnings to support medicinal chemistry drug-discovery. Previous experience in both structure-based and ligand-based drug design. Previous experience with in silico ADMET assessments, using computational methods